Presynaptic receptors are sites at which transmitters, locally formed mediators or hormones
inhibit or facilitate the release of a given transmitter from its axon terminals. The interest in …

Rasmussen's encephalitis (RE) is rare neurological diseases characterized as epilepsia
partialis continua, invariably hemiparesis, and cognitive impairment. This disease is …

Motor skill training induces structural plasticity at dendritic spines in the primary motor cortex
(M1). To further analyze both synaptic and intrinsic plasticity in the layer II/III area of M1, we …

When it comes to the human brain, models that closely mimic in vivo conditions are lacking.
Living neuronal tissue is the closest representation of the in vivo human brain outside of a …

Objective Altered functional activities and hypometabolism have been found in medial
temporal lobe epilepsy patients with hippocampal sclerosis (mTLE‐HS). Hybrid PET/MR …

Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological
conditions. A classical way of controlling tonic inhibition is through pharmacological …

Abstract γ-Aminobutyric acid (GABA) and glutamate (Glu) are the main inhibitory and
excitatory neurotransmitters in the central nervous system (CNS), respectively. Fine tuning …

Depressive disorder is the leading cause of disability worldwide, yet the mechanisms
underlying depression are not fully understood. Vesicle release is essential for synaptic …

GSK-126 is recognized as an inhibitor of enhancer of zeste homolog-2 (EZH2) activity.
Because of its inhibition of EZH2 activation, GSK-126 is considered a potential anti-tumor …

Extracts of the tropical Cinderella plant Synedrella nodiflora are used traditionally to manage
convulsive conditions in the West African sub-region. This study sought to determine the …