m6A RNA methylation: from mechanisms to therapeutic potential

PC He, C He - The EMBO journal, 2021 - embopress.org
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …

The potential role of RNA N6-methyladenosine in Cancer progression

T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …

O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins

Y Chen, R Wan, Z Zou, L Lao, G Shao, Y Zheng… - Nature Cell …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide
modification in mammals, regulating critical aspects of cell physiology and differentiation …

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

Q Wang, C Chen, Q Ding, Y Zhao, Z Wang, J Chen… - Gut, 2020 - gut.bmj.com
Objective N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase
METTL3 are involved in tumour initiation and progression via the regulation of RNA function …

Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

M Wang, J Liu, Y Zhao, R He, X Xu, X Guo, X Li, S Xu… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal human cancers. N 6-
methyladenosine (m 6 A), a common eukaryotic mRNA modification, plays critical roles in …

RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent

X Wang, L Tian, Y Li, J Wang, B Yan, L Yang… - Journal of Experimental …, 2021 - Springer
Background Laryngeal cancer has the highest mortality rate among head and neck tumours.
RNA N6-methyladenosine (m6A) is the most plentiful and variable in mammalian mRNA …

m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin

D Liang, WJ Lin, M Ren, J Qiu, C Yang, X Wang, N Li… - Autophagy, 2022 - Taylor & Francis
Dysregulation of macroautophagy/autophagy contributes to the delay of wound healing in
diabetic skin. N6-methyladenosine (m6A) RNA modification is known to play a critical role in …

[HTML][HTML] Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders

Z Yang, G Yu, X Zhu, T Peng, Y Lv - Genes & diseases, 2022 - Elsevier
The goal this review is to clarify the effects of the fat mass and obesity-associated protein
(FTO) in lipid metabolism regulation and related underlying mechanisms through the FTO …

The evolving landscape of N6-methyladenosine modification in the tumor microenvironment

Y Gu, X Wu, J Zhang, Y Fang, Y Pan, Y Shu, P Ma - Molecular Therapy, 2021 - cell.com
The tumor microenvironment (TME), controlled by intrinsic mechanisms of carcinogenesis
and epigenetic modifications, has, in recent years, become a heavily researched topic. The …

m6A RNA methylation in cardiovascular diseases

S Wu, S Zhang, X Wu, X Zhou - Molecular Therapy, 2020 - cell.com
Cardiovascular diseases (CVDs) remain the leading cause of death and disability
worldwide, despite marked improvements in prevention, diagnosis, and early intervention …