Obesity-related hypogonadotropic hypogonadism is a well-characterized condition in men
(termed male obesity-related secondary hypogonadism; MOSH); however, an equivalent …

Fatty acids are not only widely known as energy sources, but also play important roles in
many metabolic pathways. The significance of fatty acids in modulating the reproductive …

Female reproduction focuses mainly on achieving fully grown follicles and competent
oocytes to be successfully fertilized, as well as on nourishing the developing offspring once …

Background Oleic acid is an abundant free fatty acid present in livestock that are in a
negative energy-balance state, and it may have detrimental effects on female reproduction …

Abstract Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor, consisting
of a constitutively expressed β-subunit (HIF1B) and a regulated α-subunit (HIF1A). In the …

A majority of common metabolic diseases can result in excessive lipolysis, leading to
elevated levels of non-esterified fatty acids (NEFAs) in the body fluids. In females, increased …

Fatty acids (FA) are one of the substrates that can be oxidized for energy production. The
blood concentration of all types of FA varies according to different nutrition conditions, and …

Ovarian cycle is controlled by circulating levels of the steroid hormone 17-β-estradiol, which
is predominantly synthesized by the granulosa cells (GCs) of ovarian follicles. Our earlier …

The peripartum period in dairy cows is frequently associated with excessive lipolysis due to
Negative Energy Balance (NEB). These metabolic disorders are the cause of various …

In brief Fertility in the dairy cow is low during the post-partum period of negative energy
balance and high plasma irisin concentrations. This study shows irisin modulates granulosa …