Primary biliary cholangitis (PBC; previously “primary biliary cirrhosis”) is a cholestatic,
putatively autoimmune-mediated liver disease with a clear female preponderance affecting …

Recent years have seen unprecedented progress in the identification and characterization
of genetic information related to chronic liver diseases (CLDs). However, despite the …

Background Patients with primary biliary cirrhosis (PBC) exhibit a variety of clinical
manifestations and patterns of disease progression. The aim of this study was to identify …

Recent genome‐wide association studies suggest that genetic factors contribute to primary
biliary cirrhosis (PBC) susceptibility. Although several reports have demonstrated that the …

原发性胆汁性肝硬化(primary biliary cirrhosis, PBC) 是一种慢性进行性胆汁淤积性自身免疫性
肝病, 以肝内小胆管破坏及血清高特异性抗线粒体抗体(antimitochondrial antibodies, AMAs) …

Background To identify the genetic factors involved in the pathogenesis of primary biliary
cirrhosis (PBC), we focused on the organic cation transporter 1 (OCT1/SLC22A1), which is …

Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a model
autoimmune disease with chronic cholestasis characterized by the hallmark of anti …

Abstract Approximately 10–20% of patients with primary biliary cholangitis (PBC) progress to
jaundice stage regardless of treatment with ursodeoxycholic acid and bezafibrate. In this …

Evidences indicate that angiogenesis is an important process in the development of
destructive synovial tissue in rheumatoid arthritis (RA). Recently, it has been shown that the …

Background Knee osteoarthritis (OA) is a complex disease involving both biomechanical
and metabolic factors that alter the tissue homeostasis of articular cartilage and subchondral …