Integrative cerebral blood flow regulation in ischemic stroke

JL Fan, P Brassard, CA Rickards… - Journal of Cerebral …, 2022 - journals.sagepub.com
Optimizing cerebral perfusion is key to rescuing salvageable ischemic brain tissue. Despite
being an important determinant of cerebral perfusion, there are no effective guidelines for …

Cerebral oxygen extraction fraction MRI: Techniques and applications

D Jiang, H Lu - Magnetic resonance in medicine, 2022 - Wiley Online Library
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults

J Cho, J Lee, H An, MS Goyal, Y Su… - Journal of Cerebral …, 2021 - journals.sagepub.com
We aimed to validate oxygen extraction fraction (OEF) estimations by quantitative
susceptibility mapping plus quantitative blood oxygen-level dependence (QSM+ qBOLD, or …

Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke

JL Fan, RC Nogueira, P Brassard… - Journal of Cerebral …, 2022 - journals.sagepub.com
Restoring perfusion to ischemic tissue is the primary goal of acute ischemic stroke care, yet
only a small portion of patients receive reperfusion treatment. Since blood pressure (BP) is …

Validation of T2‐based oxygen extraction fraction measurement with 15O positron emission tomography

D Jiang, S Deng, CG Franklin, M O'Boyle… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To evaluate the accuracy of T2‐based whole‐brain oxygen extraction fraction
(OEF) estimation by comparing it with gold standard 15O‐PET measurements. Methods …

[HTML][HTML] Cerebral blood flow quantification with multi-delay arterial spin labeling in ischemic stroke and the association with early neurological outcome

SPR Luijten, D Bos, PJ van Doormaal, M Goyal… - NeuroImage: Clinical, 2023 - Elsevier
Restoring blood flow to brain tissue at risk of infarction is essential for tissue survival and
clinical outcome. We used cerebral blood flow (CBF) quantified with multiple post-labeling …

Prevalence and significance of the vessel-cluster sign on susceptibility-weighted imaging in patients with severe small vessel disease

S Rudilosso, E Chui, MS Stringer, M Thrippleton… - Neurology, 2022 - AAN Enterprises
Background and Objectives Magnetic resonance susceptibility-weighted imaging (SWI) can
identify small brain blood vessels that contain deoxygenated blood due to its induced …

Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping

H Lee, J Xu, MA Fernandez-Seara… - Journal of Cerebral …, 2024 - journals.sagepub.com
Quantitative BOLD (qBOLD) MRI allows evaluation of oxidative metabolism of the brain
based purely on an endogenous contrast mechanism. The method quantifies deoxygenated …

Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology

Z Lin, C Lim, D Jiang, A Soldan… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Oxygen extraction fraction (OEF) reflects the balance between oxygen delivery
and consumption. We longitudinally measured OEF in older adults to examine the …

Investigating the accuracy and precision of TE‐dependent versus multi‐echo QSM using Laplacian‐based methods at 3 T

E Biondetti, A Karsa, DL Thomas… - Magnetic resonance in …, 2020 - Wiley Online Library
Purpose Multi‐echo gradient‐recalled echo acquisitions for QSM enable optimizing the SNR
for several tissue types through multi‐echo (TE) combination or investigating temporal …