Epidemiology of uterine fibroids: a systematic review

EA Stewart, CL Cookson, RA Gandolfo… - … Journal of Obstetrics …, 2017 - Wiley Online Library
Background Uterine fibroids (UF s) are the most common neoplasm affecting women that
can cause significant morbidity and may adversely impact fertility. Objectives To examine UF …

Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics

MS Islam, A Ciavattini, F Petraglia… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Uterine fibroid management: from the present to the future

J Donnez, MM Dolmans - Human reproduction update, 2016 - academic.oup.com
Uterine fibroids (also known as leiomyomas or myomas) are the most common form of
benign uterine tumors. Clinical presentations include abnormal bleeding, pelvic masses …

Hormones and pathogenesis of uterine fibroids

FM Reis, E Bloise, TM Ortiga-Carvalho - Best Practice & Research Clinical …, 2016 - Elsevier
Highlights•Both estradiol and progesterone are essential for uterine fibroid
development.•Ovarian blockade arrests leiomyoma growth, but it has many side …

Selective progesterone receptor modulators—mechanisms and therapeutic utility

MS Islam, S Afrin, SI Jones, J Segars - Endocrine Reviews, 2020 - academic.oup.com
Selective progesterone receptor modulators (SPRMs) are a new class of compounds
developed to target the progesterone receptor (PR) with a mix of agonist and antagonist …

Signaling pathways in leiomyoma: understanding pathobiology and implications for therapy

MA Borahay, A Al-Hendy, GS Kilic, D Boehning - Molecular medicine, 2015 - Springer
Uterine leiomyomas are the most common tumors of the female genital tract, affecting 50%
to 70% of females by the age of 50. Despite their prevalence and enormous medical and …

Myomas and adenomyosis: impact on reproductive outcome

NF Vlahos, TD Theodoridis… - BioMed research …, 2017 - Wiley Online Library
Among uterine structural abnormalities, myomas and adenomyosis represent two distinct,
though frequently coexistent entities, with a remarkable prevalence in women of …

Possible involvement of inflammatory/reparative processes in the development of uterine fibroids

O Protic, P Toti, MS Islam, R Occhini… - Cell and tissue …, 2016 - Springer
Uterine leiomyomas are benign tumors in the smooth muscle layer of the uterus. The most
common histological type is the “usual leiomyoma”, characterized by overexpression of ECM …

Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics

M Ali, M Ciebiera, S Vafaei, S Alkhrait, HY Chen… - Cells, 2023 - mdpi.com
Uterine fibroids (UFs) are the most important benign neoplastic threat to women's health
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …

[HTML][HTML] First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids

M Luyckx, JL Squifflet, P Jadoul, R Votino… - Fertility and sterility, 2014 - Elsevier
Objective To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
Design Retrospective analysis of a series of 52 patients prospectively included in the …