The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …

The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …

Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Gene therapy using nucleic acids has many clinical applications for the treatment of
diseases with a genetic origin as well as for the development of innovative vaccine …

Biodegradable polymers have been widely used and have greatly promoted the
development of biomedical fields because of their biocompatibility and biodegradability. The …

Polycations such as polyethylenimine (PEI) are used in many novel nonviral vector designs
and there are continuous efforts to increase our mechanistic understanding of their …

Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

Gene therapy has emerged as a promising approach for the treatment or prevention of
acquired and genetic diseases. At the present time, major somatic gene transfer approaches …