OBJECTIVE: To illustrate the necessity for an enhanced understanding of the genetic basis
of male factor infertility, to present a comprehensive synopsis of these genetic elements, and …

Male infertility represents one of the clearest examples of a complex disease with a
substantial genetic basis. Numerous male mouse models, mutation screening and …

FSH was first identified in 1930 and is central to mammalian reproduction. It is indeed
intriguing that despite being researched upon for about 90 years, there is still so much more …

Genetic causes account for 10–15% of severe male infertility, including chromosomal
aberrations and single gene mutations. Natural selection prevents the transmission of …

Azoospermia due to obstructive and non-obstructive mechanisms is a common
manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors …

Gonadotropin therapy to treat specific male infertility disorders associated with
hypogonadotropic hypogonadism is evidence-based and effective in restoring …

Many genetic polymorphisms have been studied extensively to elucidate their role in the
pathophysiology of male infertility. This article presents a review of the literature following a …

The p. N680S sequence variation of the follicle-stimulating hormone (FSH) receptor gene
was previously shown to influence the ovarian response to FSH in normo-ovulatory women …

Objective To assess the pharmacogenetic potential of FSH for infertility treatment. Design
Review of the literature and genomic databases. Methods Single-nucleotide polymorphism …

FSH brings about its physiological actions by activating a specific receptor located on target
cells. Normal functioning of the FSH receptor (FSHR) is crucial for follicular development …