Genetics of osteoporosis

SH Ralston, AG Uitterlinden - Endocrine reviews, 2010 - academic.oup.com
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Genetic regulation of bone mass and susceptibility to osteoporosis

SH Ralston, B de Crombrugghe - Genes & development, 2006 - genesdev.cshlp.org
Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass and increased risk of fragility fractures. Twin and family studies have …

[HTML][HTML] Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis …

SC Tao, T Yuan, BY Rui, ZZ Zhu, SC Guo… - Theranostics, 2017 - ncbi.nlm.nih.gov
An excess of glucocorticoids (GCs) is reported to be one of the most common causes of
osteonecrosis of the femoral head (ONFH). In addition, GCs can induce bone cell apoptosis …

[图书][B] Генетический паспорт–основа индивидуальной и предиктивной медицины

В Баранов - 2022 - books.google.com
В доступной форме в книге изложены основные события, произошедшие в
медицинской генетике и в молекулярной медицине после расшифровки генома …

[HTML][HTML] Genome-wide association with bone mass and geometry in the Framingham Heart Study

DP Kiel, S Demissie, J Dupuis, KL Lunetta… - BMC medical …, 2007 - Springer
Background Osteoporosis is characterized by low bone mass and compromised bone
structure, heritable traits that contribute to fracture risk. There have been no genome-wide …

[HTML][HTML] Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head

M Zhou, J Xi, Y Cheng, D Sun, P Shu, S Chi… - Stem cell research & …, 2021 - Springer
Background Cellular therapy based on mesenchymal stem cells (MSCs) is a promising
novel therapeutic strategy for the osteonecrosis of the femoral head (ONFH), which is …

Genetic control of susceptibility to osteoporosis

SH Ralston - The Journal of Clinical Endocrinology & …, 2002 - academic.oup.com
Osteoporosis is a common disease with a strong genetic component. Twin studies have
shown that genetic factors play an important role in regulating bone mineral density (BMD) …

[HTML][HTML] Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study

SH Ralston, AG Uitterlinden, ML Brandi… - PLoS …, 2006 - journals.plos.org
Background Osteoporosis and fracture risk are considered to be under genetic control.
Extensive work is being performed to identify the exact genetic variants that determine this …

Genetics of osteoporosis: accelerating pace in gene identification and validation

WF Li, SX Hou, B Yu, MM Li, C Férec, JM Chen - Human genetics, 2010 - Springer
Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …

Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players

K Ficek, P Cieszczyk, M Kaczmarczyk… - Journal of science and …, 2013 - Elsevier
Objectives To examine the association of the COL1A1− 1997G/T and+ 1245G/T
polymorphisms, individually and as haplotypes, with anterior cruciate ligament ruptures in …