Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Atherosclerosis is an inflammatory disease resulting in the hardening and thickening of the
wall of arteries and the formation of plaques, which comprise immune cells, mesenchymal …

Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

Cerebral cavernous malformation (CCM) is a vascular dysplasia, mainly localized within the
brain and affecting up to 0.5% of the human population. CCM lesions are formed by …

Recent evidence has demonstrated that endothelial cells can have a remarkable plasticity.
By a process called Endothelial-to-Mesenchymal Transition (EndMT) endothelial cells …

Endothelial cells form cell–cell adhesive structures, called adherens and tight junctions,
which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the …

Angiogenesis is a hallmark of cancer. However, most malignant solid tumors exhibit robust
resistance to current anti-angiogenic therapies that primarily target VEGF pathways. Here …

Endothelial–mesenchymal transition (EndMT) is an important source of cancer-associated
fibroblasts (CAFs), which facilitates tumour progression. PDAC is characterised by abundant …

Purpose.: Hyperglycemia-induced endothelial damage is a key pathogenetic factor in
diabetic retinopathy. Endothelial damage may lead to phenotypic changes in the cells …