Ru (II) compounds: next-generation anticancer metallotherapeutics?

S Thota, DA Rodrigues, DC Crans… - Journal of medicinal …, 2018 - ACS Publications
Metal based therapeutics are a precious class of drugs in oncology research that include
examples of theranostic drugs, which are active in both diagnostic, specifically imaging, and …

[HTML][HTML] Anticancer ruthenium (III) complexes and Ru (III)-containing nanoformulations: An update on the mechanism of action and biological activity

C Riccardi, D Musumeci, M Trifuoggi, C Irace… - Pharmaceuticals, 2019 - mdpi.com
The great advances in the studies on metal complexes for the treatment of different cancer
forms, starting from the pioneering works on platinum derivatives, have fostered an …

Synthesis, characterization of ruthenium (II), nickel (II), palladium (II), and platinum (II) triphenylphosphine-based complexes bearing an ONS-donor chelating agent …

SA Elsayed, HE Badr, A di Biase… - Journal of Inorganic …, 2021 - Elsevier
Four new transition metal complexes,[M (PPh 3)(L)]. CH 3 OH (M= Ni (II)(1), Pd (II)(2))[Pt
(PPh 3) 2 (HL)] Cl (3) and [Ru (CO)(PPh 3) 2 (L)](4)(H 2 L= 2, 4-dihydroxybenzaldehyde-S …

Triarylphosphine-coordinated bipyridyl Ru (II) complexes induce mitochondrial dysfunction

RJ Mitchell, AS Gowda, AG Olivelli… - Inorganic …, 2023 - ACS Publications
While cancer cells rely heavily upon glycolysis to meet their energetic needs, reducing the
importance of mitochondrial oxidative respiration processes, more recent studies have …

Anticancer effects of phytol against Sarcoma (S-180) and Human Leukemic (HL-60) cancer cells

MVOB de Alencar, MT Islam, AMOF da Mata… - … Science and Pollution …, 2023 - Springer
Abstract Phytol (Pyt), a diterpenoid, possesses many important bioactivities. This study
evaluates the anticancer effects of Pyt on sarcoma 180 (S-180) and human leukemia (HL …

[HTML][HTML] Synthesis of Pd/Ru Bimetallic Nanoparticles by Escherichia coli and Potential as a Catalyst for Upgrading 5-Hydroxymethyl Furfural Into Liquid Fuel …

J Gomez-Bolivar, IP Mikheenko, RL Orozco… - Frontiers in …, 2019 - frontiersin.org
Escherichia coli cells support the nucleation and growth of ruthenium and ruthenium-
palladium nanoparticles (Bio-Ru and Bio-Pd/Ru NPs). We report a method for the synthesis …

Light-triggered dissociation of self-assembled β-amyloid aggregates into small, nontoxic fragments by ruthenium (II) complex

G Son, BI Lee, YJ Chung, CB Park - Acta biomaterialia, 2018 - Elsevier
The self-assembly of β-amyloid (Aβ) peptides into highly stable plaques is a major hallmark
of Alzheimer's disease. Here, we report visible light-driven dissociation of β-sheet-rich Aβ …

[HTML][HTML] Novel catalytically active Pd/Ru bimetallic nanoparticles synthesized by Bacillus benzeovorans

JB Omajali, J Gomez-Bolivar, IP Mikheenko… - Scientific reports, 2019 - nature.com
Bacillus benzeovorans assisted and supported growth of ruthenium (bio-Ru) and
palladium/ruthenium (bio-Pd@ Ru) core@ shell nanoparticles (NPs) as bio-derived …

[HTML][HTML] Emerging molecular receptors for the specific-target delivery of ruthenium and gold complexes into cancer cells

JF Machado, JDG Correia, TS Morais - Molecules, 2021 - mdpi.com
Cisplatin and derivatives are highly effective in the treatment of a wide range of cancer
types; however, these metallodrugs display low selectivity, leading to severe side effects …

Ru (II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis

F Mello-Andrade, APM Guedes, WC Pires… - Journal of Inorganic …, 2022 - Elsevier
For some cancer subtypes, such as triple-negative breast cancer, there are no specific
therapies, which leads to a poor prognosis associated with invasion and metastases …