Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …

Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the
precise mechanisms is incomplete. Here, we investigate how insulin resistance alters …

Tissues release microRNAs (miRNAs) in small extracellular vesicles (sEVs) including
exosomes, which can regulate gene expression in distal cells, thus acting as modulators of …

The glucose transporter GLUT4 is integral for optimal skeletal muscle performance during
exercise, as well as for metabolic health. Physiological regulation of GLUT4 translocation …

Precision diabetes medicine (PDM) aims to reduce errors in prevention programmes,
diagnosis thresholds, prognosis prediction and treatment strategies. However, its …

The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral
immunity. RLR signaling also triggers glycolytic reprogramming through glucose …

Background Insulin signaling regulates cardiac substrate utilization and is implicated in
physiological adaptations of the heart. Alterations in the signaling response within the heart …

Sensitivity and plasticity of insulin signaling and glucose uptake in skeletal muscle depends
on determinants such as genetic variation and obesity. We collected muscle biopsies and …

Obesity, characterized by enlarged and dysfunctional adipose tissue, is among today's most
pressing global public health challenges with continuously increasing prevalence. Despite …

The ability of insulin to stimulate glucose transport in muscle and fat cells is mediated by the
regulated delivery of intracellular vesicles containing glucose transporter-4 (GLUT4) to the …