This paper reviews our present knowledge on the contribution of ceramide (Cer),
sphingomyelin (SM), dihydroceramide (DhCer) and sphingosine-1-phosphate (S1P) in …

Neurodegenerative diseases are characterized by adverse cellular environments and
pathological alterations causing neurodegeneration in distinct brain regions. This …

Summary Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid metabolite. The past
decade has witnessed exponential growth in the field of S1P research, partly attributed to …

Pathological vascular remodeling is observed in various cardiovascular diseases including
pulmonary hypertension (PH), a disease of unknown etiology that has been characterized …

Central nervous system and visual dysfunction is an unfortunate consequence of systemic
hypoxia in the setting of cardiopulmonary disease, including infection with SARS-CoV-2 …

Abstract Sphingosine-1-phosphate (S1P) is emerging as a hypoxia responsive bio-lipid;
systemically raised levels of S1P are proposed to have potential hypoxia pre-conditioning …

Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine
signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing …

Abstract Sphingosine 1-phosphate (S1P) is an important immune modulator responsible for
physiological cellular responses like lymphocyte development and function, positioning and …

Preeclampsia (PE), a hypertensive multisystem disorder, can lead to increased maternal
and fetal mortality and morbidity. Sphingosine‑1‑phosphate (S1P) plays various roles …

Ischemic and reperfusion injuries of the heart underlie the pathogenesis of acute myocardial
infarction (AMI) and sudden cardiac death. The mortality rate is still high and is 5–7% in …