Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Differences in the prevalence of chronic pain in women vs. men are well known, and
decades of laboratory experimentation have demonstrated that women are more sensitive to …

Comorbid depression and chronic pain are highly prevalent in individuals suffering from
physical illness. Here, we critically examine the possibility that inflammation is the common …

Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …