Antiviral approaches against influenza virus

R Kumari, SD Sharma, A Kumar, Z Ende… - Clinical microbiology …, 2023 - Am Soc Microbiol
Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …

Tackling Influenza A virus by M2 ion channel blockers: Latest progress and limitations

G Kumar, KA Sakharam - European Journal of Medicinal Chemistry, 2024 - Elsevier
Influenza outbreaks cause pandemics in millions of people. The treatment of influenza
remains a challenge due to significant genetic polymorphism in the influenza virus. Also …

Robust Antiviral Activity of Santonica Flower Extract (Artemisia cina) against Avian and Human Influenza A Viruses: In Vitro and Chemoinformatic Studies

A Hegazy, I Mostafa, YAMM Elshaier, SH Mahmoud… - ACS …, 2022 - ACS Publications
The evolution of drug-resistant viral strains following natural acquisition of resistance
mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the …

Dual oxidase 1 promotes antiviral innate immunity

D Sarr, AD Gingerich, NM Asthiwi… - Proceedings of the …, 2021 - National Acad Sciences
Dual oxidase 1 (DUOX1) is an NADPH oxidase that is highly expre-ssed in respiratory
epithelial cells and produces H2O2 in the airway lumen. While a line of prior in vitro …

Comprehensive analysis of lipid metabolism in influenza virus infection

X Chen, S Wang, P Gan, J Zhang, G Tong, S Liu - Microbial Pathogenesis, 2023 - Elsevier
Influenza A virus (IAV) exploits host metabolic pathways to support its replication. To
improve the understanding of lipid metabolic changes that could occur upon IAV infection, a …

[HTML][HTML] The convergent evolution of influenza A virus: Implications, therapeutic strategies and what we need to know

ZY Low, KH Wong, AJW Yip, WS Choo - Current Research in Microbial …, 2023 - Elsevier
Influenza virus infection, more commonly known as the 'cold flu', is an etiological agent that
gives rise to recurrent annual flu and many pandemics. Dated back to the 1918-Spanish Flu …

Inhibition of influenza virus replication by Apiaceae plants, with special reference to Peucedanum japonicum (Sacna) constituents

R Kanazawa, R Morimoto, Y Horio, H Sumitani… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Apiaceae plants possess various pharmacological
properties, such as antimicrobial, antioxidant, hypoglycemic, hypolipidemic, anxiolytic …

Broadly protective neuraminidase-based influenza vaccines and monoclonal antibodies: Target epitopes and mechanisms of action

N Abbadi, JJ Mousa - Viruses, 2023 - mdpi.com
Neuraminidase (NA) is an important surface protein on influenza virions, playing an
essential role in the viral life cycle and being a key target of the immune system. Despite the …

Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges

CH Masterson, A Ceccato, A Artigas… - Intensive care medicine …, 2021 - Springer
Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether
due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating …

Structural investigations and binding mechanisms of oseltamivir drug resistance conferred by the E119V mutation in influenza H7N9 virus

SC Ugbaja, SE Mtambo, AG Mushebenge… - Molecules, 2022 - mdpi.com
The use of vaccinations and antiviral medications have gained popularity in the therapeutic
management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due …