Antiviral approaches against influenza virus
Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …
Tackling Influenza A virus by M2 ion channel blockers: Latest progress and limitations
G Kumar, KA Sakharam - European Journal of Medicinal Chemistry, 2024 - Elsevier
Influenza outbreaks cause pandemics in millions of people. The treatment of influenza
remains a challenge due to significant genetic polymorphism in the influenza virus. Also …
remains a challenge due to significant genetic polymorphism in the influenza virus. Also …
Robust Antiviral Activity of Santonica Flower Extract (Artemisia cina) against Avian and Human Influenza A Viruses: In Vitro and Chemoinformatic Studies
The evolution of drug-resistant viral strains following natural acquisition of resistance
mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the …
mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the …
Dual oxidase 1 promotes antiviral innate immunity
D Sarr, AD Gingerich, NM Asthiwi… - Proceedings of the …, 2021 - National Acad Sciences
Dual oxidase 1 (DUOX1) is an NADPH oxidase that is highly expre-ssed in respiratory
epithelial cells and produces H2O2 in the airway lumen. While a line of prior in vitro …
epithelial cells and produces H2O2 in the airway lumen. While a line of prior in vitro …
Comprehensive analysis of lipid metabolism in influenza virus infection
X Chen, S Wang, P Gan, J Zhang, G Tong, S Liu - Microbial Pathogenesis, 2023 - Elsevier
Influenza A virus (IAV) exploits host metabolic pathways to support its replication. To
improve the understanding of lipid metabolic changes that could occur upon IAV infection, a …
improve the understanding of lipid metabolic changes that could occur upon IAV infection, a …
[HTML][HTML] The convergent evolution of influenza A virus: Implications, therapeutic strategies and what we need to know
Influenza virus infection, more commonly known as the 'cold flu', is an etiological agent that
gives rise to recurrent annual flu and many pandemics. Dated back to the 1918-Spanish Flu …
gives rise to recurrent annual flu and many pandemics. Dated back to the 1918-Spanish Flu …
Inhibition of influenza virus replication by Apiaceae plants, with special reference to Peucedanum japonicum (Sacna) constituents
R Kanazawa, R Morimoto, Y Horio, H Sumitani… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Apiaceae plants possess various pharmacological
properties, such as antimicrobial, antioxidant, hypoglycemic, hypolipidemic, anxiolytic …
properties, such as antimicrobial, antioxidant, hypoglycemic, hypolipidemic, anxiolytic …
Broadly protective neuraminidase-based influenza vaccines and monoclonal antibodies: Target epitopes and mechanisms of action
N Abbadi, JJ Mousa - Viruses, 2023 - mdpi.com
Neuraminidase (NA) is an important surface protein on influenza virions, playing an
essential role in the viral life cycle and being a key target of the immune system. Despite the …
essential role in the viral life cycle and being a key target of the immune system. Despite the …
Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges
CH Masterson, A Ceccato, A Artigas… - Intensive care medicine …, 2021 - Springer
Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether
due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating …
due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating …
Structural investigations and binding mechanisms of oseltamivir drug resistance conferred by the E119V mutation in influenza H7N9 virus
The use of vaccinations and antiviral medications have gained popularity in the therapeutic
management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due …
management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due …