Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …

The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …

The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

Glioblastoma (GB) is the most frequent and aggressive primary tumor of the central nervous
system. Prognosis remains poor despite ongoing progress. In cases where the gadolinium …

Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …

Introduction Convection-enhanced delivery (CED) is a method of targeted, local drug
delivery to the central nervous system (CNS) that bypasses the blood-brain barrier (BBB) …