Exploring the mechanical perspective of a new anti-tumor agent: melatonin
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …
Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy
Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …
Baicalin prevents myocardial ischemia/reperfusion injury through inhibiting ACSL4 mediated ferroptosis
Z Fan, L Cai, S Wang, J Wang, B Chen - Frontiers in Pharmacology, 2021 - frontiersin.org
Baicalin is a natural flavonoid glycoside that confers protection against myocardial
ischemia/reperfusion (I/R) injury. However, its mechanism has not been fully understood …
ischemia/reperfusion (I/R) injury. However, its mechanism has not been fully understood …
Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells
It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …
[HTML][HTML] Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways
Y Mi, C Wei, L Sun, H Liu, J Zhang, J Luo, X Yu… - Biomedicine & …, 2023 - Elsevier
Background Cataracts are the main cause of reversible blindness worldwide. The ageing of
the lens caused by ultraviolet B (UVB) radiation is mostly related to oxidative stress (OS) …
the lens caused by ultraviolet B (UVB) radiation is mostly related to oxidative stress (OS) …
Autophagy in age‐related macular degeneration: a regulatory mechanism of oxidative stress
ZY Zhang, XL Bao, YY Cong, B Fan… - Oxidative medicine and …, 2020 - Wiley Online Library
Age‐related macular degeneration (AMD) is a leading cause of severe visual loss and
irreversible blindness in the elderly population worldwide. Retinal pigment epithelial (RPE) …
irreversible blindness in the elderly population worldwide. Retinal pigment epithelial (RPE) …
[HTML][HTML] Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases
R Tabassum, NY Jeong - International Journal of Medical Sciences, 2019 - ncbi.nlm.nih.gov
Oxidative phosphorylation is a source of energy production by which many cells satisfy their
energy requirements. Endogenous reactive oxygen species (ROS) are by-products of …
energy requirements. Endogenous reactive oxygen species (ROS) are by-products of …
[HTML][HTML] Eugenol-induced autophagy and apoptosis in breast cancer cells via PI3K/AKT/FOXO3a pathway inhibition
ML Abdullah, O Al-Shabanah, ZK Hassan… - International Journal of …, 2021 - mdpi.com
The use of natural compounds is promising in approaches to prevent and treat cancer. The
long-term application of most currently employed chemotherapy techniques has toxic side …
long-term application of most currently employed chemotherapy techniques has toxic side …
Autophagy dysfunction, cellular senescence, and abnormal immune‐inflammatory responses in AMD: From mechanisms to therapeutic potential
S Wang, X Wang, Y Cheng, W Ouyang… - Oxidative medicine …, 2019 - Wiley Online Library
Age‐related macular degeneration (AMD) is a blinding disease caused by multiple factors
and is the primary cause of vision loss in the elderly. The morbidity of AMD increases every …
and is the primary cause of vision loss in the elderly. The morbidity of AMD increases every …
FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury
L Hou, S Li, S Li, R Wang, M Zhao, X Liu - Journal of physiology and …, 2023 - Springer
Current therapies are of limited efficacy in cerebral ischemia/reperfusion (I/R) injury. Based
on the important role of oxidative stress in cerebral I/R injury, this study aimed to explore …
on the important role of oxidative stress in cerebral I/R injury, this study aimed to explore …