Exploring the mechanical perspective of a new anti-tumor agent: melatonin

S Rohilla, M Singh, S Priya, WH Almalki… - Journal of …, 2023 - dl.begellhouse.com
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …

Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy

N Targhazeh, RJ Reiter, M Rahimi, D Qujeq, T Yousefi… - Biochimie, 2022 - Elsevier
Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …

Baicalin prevents myocardial ischemia/reperfusion injury through inhibiting ACSL4 mediated ferroptosis

Z Fan, L Cai, S Wang, J Wang, B Chen - Frontiers in Pharmacology, 2021 - frontiersin.org
Baicalin is a natural flavonoid glycoside that confers protection against myocardial
ischemia/reperfusion (I/R) injury. However, its mechanism has not been fully understood …

Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells

DX Tan, RJ Reiter - Melatonin research, 2019 - melatonin-research.net
It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …

[HTML][HTML] Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways

Y Mi, C Wei, L Sun, H Liu, J Zhang, J Luo, X Yu… - Biomedicine & …, 2023 - Elsevier
Background Cataracts are the main cause of reversible blindness worldwide. The ageing of
the lens caused by ultraviolet B (UVB) radiation is mostly related to oxidative stress (OS) …

Autophagy in age‐related macular degeneration: a regulatory mechanism of oxidative stress

ZY Zhang, XL Bao, YY Cong, B Fan… - Oxidative medicine and …, 2020 - Wiley Online Library
Age‐related macular degeneration (AMD) is a leading cause of severe visual loss and
irreversible blindness in the elderly population worldwide. Retinal pigment epithelial (RPE) …

[HTML][HTML] Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases

R Tabassum, NY Jeong - International Journal of Medical Sciences, 2019 - ncbi.nlm.nih.gov
Oxidative phosphorylation is a source of energy production by which many cells satisfy their
energy requirements. Endogenous reactive oxygen species (ROS) are by-products of …

[HTML][HTML] Eugenol-induced autophagy and apoptosis in breast cancer cells via PI3K/AKT/FOXO3a pathway inhibition

ML Abdullah, O Al-Shabanah, ZK Hassan… - International Journal of …, 2021 - mdpi.com
The use of natural compounds is promising in approaches to prevent and treat cancer. The
long-term application of most currently employed chemotherapy techniques has toxic side …

Autophagy dysfunction, cellular senescence, and abnormal immune‐inflammatory responses in AMD: From mechanisms to therapeutic potential

S Wang, X Wang, Y Cheng, W Ouyang… - Oxidative medicine …, 2019 - Wiley Online Library
Age‐related macular degeneration (AMD) is a blinding disease caused by multiple factors
and is the primary cause of vision loss in the elderly. The morbidity of AMD increases every …

FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury

L Hou, S Li, S Li, R Wang, M Zhao, X Liu - Journal of physiology and …, 2023 - Springer
Current therapies are of limited efficacy in cerebral ischemia/reperfusion (I/R) injury. Based
on the important role of oxidative stress in cerebral I/R injury, this study aimed to explore …