Mitotic spindle assembly in animal cells: a fine balancing act

SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Microtubule nucleation by γ-tubulin complexes and beyond

CA Tovey, PT Conduit - Essays in biochemistry, 2018 - portlandpress.com
In this short review, we give an overview of microtubule nucleation within cells. It is nearly 30
years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for …

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

C Sánchez-Huertas, F Freixo, R Viais, C Lacasa… - Nature …, 2016 - nature.com
Neurons display a highly polarized microtubule network that mediates trafficking throughout
the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn …

The where, when and how of microtubule nucleation–one ring to rule them all

N Teixidó-Travesa, J Roig, J Lüders - Journal of cell science, 2012 - journals.biologists.com
The function of microtubules depends on their arrangement into highly ordered arrays.
Spatio-temporal control over the formation of new microtubules and regulation of their …

Molecular architecture of the augmin complex

CA Gabel, Z Li, AG DeMarco, Z Zhang, J Yang… - Nature …, 2022 - nature.com
Accurate segregation of chromosomes during mitosis depends on the correct assembly of
the mitotic spindle, a bipolar structure composed mainly of microtubules. The augmin …

Identification of a novel Wnt5a–CK1ε–Dvl2–Plk1‐mediated primary cilia disassembly pathway

KH Lee, Y Johmura, LR Yu, JE Park, Y Gao… - The EMBO …, 2012 - embopress.org
Non‐motile primary cilium is an antenna‐like structure whose defect is associated with a
wide range of pathologies, including developmental disorders and cancer. Although …

Microtubule assembly during mitosis–from distinct origins to distinct functions?

S Meunier, I Vernos - Journal of cell science, 2012 - journals.biologists.com
The mitotic spindle is structurally and functionally defined by its main component, the
microtubules (MTs). The MTs making up the spindle have various functions, organization …

Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence

T Lin, A Neuner, E Schiebel - Trends in cell biology, 2015 - cell.com
Organisms with closed or open mitosis have differentially evolved various gamma-tubulin
complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays …

Acentrosomal microtubule assembly in mitosis: the where, when, and how

S Meunier, I Vernos - Trends in cell biology, 2016 - cell.com
In mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that
segregates the duplicated chromosomes into two daughter cells. Most animal cells enter …

TONNEAU2/FASS Regulates the Geometry of Microtubule Nucleation and Cortical Array Organization in Interphase Arabidopsis Cells

A Kirik, DW Ehrhardt, V Kirik - The Plant Cell, 2012 - academic.oup.com
Organization of microtubules into ordered arrays involves spatial and temporal regulation of
microtubule nucleation. Here, we show that acentrosomal microtubule nucleation in plant …