[HTML][HTML] The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
[HTML][HTML] The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …
[HTML][HTML] Saponins: research progress and their potential role in the post-COVID-19 pandemic era
D Mieres-Castro, F Mora-Poblete - Pharmaceutics, 2023 - mdpi.com
In the post-COVID-19 pandemic era, the new global situation and the limited therapeutic
management of the disease make it necessary to take urgent measures in more effective …
management of the disease make it necessary to take urgent measures in more effective …
[HTML][HTML] Exploration of the immuno-adjuvant effect and mechanism of Anemoside B4 through network pharmacology and experiment verification
L Shen, H Luo, L Fan, Z Su, S Yu, S Cao, X Wu - Phytomedicine, 2024 - Elsevier
Background Extensive investigation has been undertaken about the utilization of saponin
adjuvants in vaccines intended for veterinary and human applications. AB4 is the main …
adjuvants in vaccines intended for veterinary and human applications. AB4 is the main …
[HTML][HTML] Overview of Nucleocapsid-Targeting Vaccines against COVID-19
A Rak, I Isakova-Sivak, L Rudenko - Vaccines, 2023 - mdpi.com
The new SARS-CoV-2 coronavirus, which emerged in late 2019, is a highly variable
causative agent of COVID-19, a contagious respiratory disease with potentially severe …
causative agent of COVID-19, a contagious respiratory disease with potentially severe …
[HTML][HTML] Unglycosylated Soluble SARS-CoV-2 Receptor Binding Domain (RBD) Produced in E. coli Combined with the Army Liposomal Formulation Containing QS21 …
A Balasubramaniyam, E Ryan, D Brown, T Hamza… - Vaccines, 2022 - mdpi.com
The emergence of novel potentially pandemic pathogens necessitates the rapid
manufacture and deployment of effective, stable, and locally manufacturable vaccines on a …
manufacture and deployment of effective, stable, and locally manufacturable vaccines on a …
[HTML][HTML] A promising self-nanoemulsifying adjuvant with plant-derived saponin D boosts immune response and exerts an anti-tumor effect
X Luo, Z Song, X Zeng, Y Ye, H Zheng, D Cai… - Frontiers in …, 2023 - frontiersin.org
Objectives The low immunogenicity of tumor antigens and unacceptable toxicity of adjuvants
has hindered the application and development of tumor vaccines. Hence, we designed a …
has hindered the application and development of tumor vaccines. Hence, we designed a …
[HTML][HTML] Combination of recombinant proteins S1/N and RBD/N as potential vaccine candidates
NJ Mendoza-Ramírez, J García-Cordero… - Vaccines, 2023 - mdpi.com
Despite all successful efforts to develop a COVID-19 vaccine, the need to evaluate
alternative antigens to produce next-generation vaccines is imperative to target emerging …
alternative antigens to produce next-generation vaccines is imperative to target emerging …
Identification of differences in the magnitude and specificity of SARS-CoV-2 nucleocapsid antibody responses in naturally infected and vaccinated individuals
PD Pushpakumara, C Jeewandara… - Clinical and …, 2024 - academic.oup.com
As there are limited data on B-cell epitopes for the nucleocapsid protein in SARS-CoV-2, we
sought to identify the immunodominant regions within the N protein, recognized by patients …
sought to identify the immunodominant regions within the N protein, recognized by patients …
The Key to Increase Immunogenicity of Next‐Generation COVID‐19 Vaccines Lies in the Inclusion of the SARS‐CoV‐2 Nucleocapsid Protein
NJ Mendoza-Ramírez, J García-Cordero… - Journal of …, 2024 - Wiley Online Library
Vaccination is one of the most effective prophylactic public health interventions for the
prevention of infectious diseases such as coronavirus disease (COVID‐19). Considering the …
prevention of infectious diseases such as coronavirus disease (COVID‐19). Considering the …