[HTML][HTML] Oxidative stress, amyloid-β peptide, and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease

DA Butterfield, D Boyd-Kimball - Journal of Alzheimer's …, 2018 - content.iospress.com
Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease
(AD) and its earlier stage, amnestic mild cognitive impairment (aMCI). One source of …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in aging and cancer

AV Kudryavtseva, GS Krasnov, AA Dmitriev… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

[HTML][HTML] Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

X Wang, W Wang, L Li, G Perry, H Lee, X Zhu - Biochimica et Biophysica …, 2014 - Elsevier
Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being
detected peripherally as well as associated with the vulnerable regions of the brain affected …

[HTML][HTML] Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

A Höhn, D Weber, T Jung, C Ott, M Hugo, B Kochlik… - Redox biology, 2017 - Elsevier
Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

[HTML][HTML] Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis

A Ashraf, J Jeandriens, HG Parkes, PW So - Redox biology, 2020 - Elsevier
Iron dyshomeostasis is implicated in Alzheimer's disease (AD) alongside β-amyloid and tau
pathologies. Despite the recent discovery of ferroptosis, an iron-dependent form cell death …

[HTML][HTML] Molecular mechanisms behind free radical scavengers function against oxidative stress

F Ahmadinejad, S Geir Møller… - Antioxidants, 2017 - mdpi.com
Accumulating evidence shows that oxidative stress is involved in a wide variety of human
diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here …

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus

P Westermark, A Andersson… - Physiological …, 2011 - journals.physiology.org
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

DA Butterfield, AM Swomley… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain

R Sultana, M Perluigi, DA Butterfield - Free Radical Biology and Medicine, 2013 - Elsevier
Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

Protein carbonyl groups as biomarkers of oxidative stress

I Dalle-Donne, R Rossi, D Giustarini, A Milzani… - Clinica chimica acta, 2003 - Elsevier
Oxidative stress, an imbalance toward the pro-oxidant side of the pro-oxidant/antioxidant
homeostasis, occurs in several human diseases. Among these diseases are those in which …