The brain‐derived neurotrophic factor, BDNF, was discovered more than 30 years ago and,
like other members of the neurotrophin family, this neuropeptide is synthetized as a …

BackgroundSchizophrenia is associated with significant cognitive impairment. However, the
pathophysiological mechanisms underlying cognitive dysfunction in schizophrenia remain …

Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized …

Background Schizophrenia is associated with patterns of aberrant neurobiological circuitry.
The disease complexity is mirrored by multiple biological interactions known to contribute to …

Background Klotho and its relationship with neurotrophic factors and cognition in
schizophrenia has not yet been investigated. In this study, the hypothesis that the blood …

The increase in presynaptic striatal dopamine is the main dopaminergic abnormality in
schizophrenia (SCZ). SCZ is primarily treated by modulating the activity of monoamine …

Objective Evidence shows that the impairment of executive function (EF) is mainly attributed
to the degeneration of frontal-striatal dopamine pathway. Glial cell line-derived neurotrophic …

Neurotrophins are signalling molecules involved in the formation and maintenance of
synapses in the brain. They can cross the blood–brain barrier and be detected in peripheral …

It has been suggested that neurotrophins are involved in the etiopathogenesis of attention-
deficit/hyperactivity disorder (ADHD). This study aimed to investigate whether there are …

Background To measure the serum levels of brain-derived neurotrophic factor (BDNF) and
glial cell line-derived neurotrophic factor (GDNF) in deficit schizophrenia (DS), in order to …