Application of CRISPR/Cas9 gene editing technique in the study of cancer treatment

C Jiang, L Meng, B Yang, X Luo - Clinical genetics, 2020 - Wiley Online Library
In recent years, gene editing, especially that using clustered regularly interspaced short
palindromic repeat (CRISPR)/Cas9, has made great progress in the field of gene function …

Extracellular interactions between fibulins and transforming growth factor (TGF)-β in physiological and pathological conditions

T Tsuda - International journal of molecular sciences, 2018 - mdpi.com
Transforming growth factor (TGF)-β is a multifunctional peptide growth factor that has a vital
role in the regulation of cell growth, differentiation, inflammation, and repair in a variety of …

A protein corona sensor array detects breast and prostate cancers

L Digiacomo, K Jafari-Khouzani, S Palchetti, D Pozzi… - Nanoscale, 2020 - pubs.rsc.org
Following exposure to human plasma (HP), nanoparticles (NPs) are coated with a
biomolecular layer referred to as a protein corona. We recently revealed that characterizing …

[HTML][HTML] A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression

S Palchetti, L Digiacomo, F Giulimondi, D Pozzi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The past three decades have witnessed fast advances in the use of cationic liposome-DNA
complexes (lipoplexes) for gene delivery applications. However, no lipoplex formulation has …

[HTML][HTML] SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A

R Gu, TD Kim, H Song, Y Sui, S Shin, S Oh… - JCI insight, 2023 - ncbi.nlm.nih.gov
The histone demethylase JMJD2A/KDM4A facilitates prostate cancer development, yet how
JMJD2A function is regulated has remained elusive. Here, we demonstrate that SET7/9 …

CRISPR technology in cancer diagnosis and treatment: opportunities and challenges

B Shademan, S Masjedi, V Karamad, A Isazadeh… - Biochemical …, 2022 - Springer
A novel gene editing tool, the Cas system, associated with the CRISPR system, is emerging
as a potential method for genome modification. This simple method, based on the adaptive …

Anatomical and immunohistochemical analyses of the fusion of the premaxillary–maxillary suture in human fetuses

L Zhu, W Ruan, W Han, W Gu - Journal of Orofacial Orthopedics …, 2024 - Springer
Purpose The development of the premaxillary–maxillary suture (PMS) in human fetuses and
a possible association between the fusion time of the PMS and maxillary deficiency were …

[PDF][PDF] MiR-126 induces myeloma cell line Karpas707 apoptosis by downregulating anti-apoptotic protein MCL

T Liu, HW Fan, S Lu, SQ Wang… - Eur Rev Med Pharmacol …, 2018 - europeanreview.org
OBJECTIVE: Myeloma seriously threats human life and health and needs more efficacy
treatment method in the clinic. MiR-126 regulates cell proliferation and apoptosis. This study …

[图书][B] The creation of reagents fibulin-1C/D and truncates for protein purification and apoptotic ability on PCa cell lines

J Shaver - 2018 - search.proquest.com
Abstract Prostate Cancer (PCa) is the most diagnosed type of cancer in men in the United
States. The 5 year survival rate in men for nonmetastatic cancer is around 100%, but when …