The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …

SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …

Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …

Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …

Recent advances in the synthesis of sulfur (VI)-fluorides has enabled incredible growth in
their application in biomolecular chemistry. This review aims to serve as a primer …

Improvement in intrinsic enzymatic features is in many instances a prerequisite for the
scalable applicability of many industrially important biocatalysts. To this end, various …

Recent years have witnessed an explosion of interest in understanding the role of
conformational dynamics both in the evolution of new enzymatic activities from existing …

Radical addition to dehydroalanine (Dha) represents an appealing, modular strategy to
access non‐canonical peptide analogues for drug discovery. Prior studies on radical …