The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

Cell division is a complex process with high energy demands. However, how cells regulate
the generation of energy required for DNA synthesis and chromosome segregation is not …

A mammalian cell houses two genomes located separately in the nucleus and mitochondria.
During evolution, communications and adaptations between these two genomes occur …

Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular
substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis …

The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

Dysregulation of the cell cycle is a hallmark of cancer that leads to aberrant cellular
proliferation. CDK4/6 are cyclin-dependent kinases activated in response to proliferative …

Cell division is a metabolically demanding process, requiring the production of large
amounts of energy and biomass. Not surprisingly therefore, a cell's decision to initiate …

The relationship between cellular metabolism and the cell cycle machinery is by no means
unidirectional. The ability of a cell to enter the cell cycle critically depends on the availability …

Adapting to changes in nutrient availability and environmental conditions is a fundamental
property of cells. This adaptation requires a multi‐directional coordination between …