Concurrent diabetes and heart failure: interplay and novel therapeutic approaches

QG Karwi, KL Ho, S Pherwani, EB Ketema… - Cardiovascular …, 2022 - academic.oup.com
Diabetes mellitus increases the risk of developing heart failure, and the co-existence of both
diseases worsens cardiovascular outcomes, hospitalization, and the progression of heart …

[HTML][HTML] Molecular Basis of Cardiomyopathies in Type 2 Diabetes

S Giardinelli, G Meliota, D Mentino, G D'Amato… - International Journal of …, 2024 - mdpi.com
Diabetic cardiomyopathy (DbCM) is a common complication in individuals with type 2
diabetes mellitus (T2DM), and its exact pathogenesis is still debated. It was hypothesized …

Prophylactic evidence of MSCs-derived exosomes in doxorubicin/trastuzumab-induced cardiotoxicity: beyond mechanistic target of NRG-1/Erb signaling pathway

N Ebrahim, HA Al Saihati, O Mostafa… - International Journal of …, 2022 - mdpi.com
Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor
receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has …

The role of levosimendan in phosphine-induced cardiotoxicity: evaluation of electrocardiographic, echocardiographic, and biochemical parameters

M Armandeh, B Bameri, M Baeeri… - Toxicology …, 2021 - Taylor & Francis
Aluminum phosphide (AlP) causes serious poisoning in which severe cardiac suppression
is the significant lethal consequence. According to evidence, levosimendan can exert …

Sacubitril and valsartan protect from experimental myocardial infarction by ameliorating oxidative damage in Wistar rats

M Imran, MQ Hassan, MS Akhtar… - Clinical and …, 2019 - Taylor & Francis
ABSTRACT Background: Sacubitril (SAC), a neprilysin inhibitor prevent degradation of
neprilysin and activate cGMP signaling pathways leading to rise in blood volume concurrent …

Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced …

MQ Hassan, MS Akhtar, O Afzal, I Hussain… - Clinical and …, 2020 - Taylor & Francis
Background: Doxorubicin (DOX) is a potential chemotherapeutic agent but its use is
restricted due to cardiotoxicity. Edaravone is a potent-free radical scavenging agent used in …

Methanolic seed extract of Vitis vinifera ameliorates oxidative stress, inflammation and ATPase dysfunction in infarcted and non-infarcted heart of streptozotocin …

N Giribabu, J Roslan, SS Rekha, N Salleh - International journal of …, 2016 - Elsevier
Background We hypothesized that consumption of Vitis vinifera seed by diabetics could help
to ameliorate myocardial damage. Therefore, in this study, we investigated effects of V …

Arrhythmogenic gene remodelling in elderly patients with type 2 diabetes with aortic stenosis and normal left ventricular ejection fraction

R Ashrafi, P Modi, AY Oo, DM Pullan… - Experimental …, 2017 - Wiley Online Library
New Findings What is the central question of this study? Type 2 diabetes is associated with
a higher rate of ventricular arrhythmias compared with the non‐diabetic population, but the …

Myocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target

A Dattani, A Singh, GP McCann, GS Gulsin - Journal of Cardiovascular …, 2023 - mdpi.com
Type 2 diabetes (T2D) is a multisystem disease with rapidly increasing global prevalence.
Heart failure has emerged as a major complication of T2D. Dysregulated myocardial calcium …

Levosimendan: mechanistic insight and its diverse future aspects in cardiac care

MS Akhtar, MQ Hassan, A Siddiqui… - Acta …, 2023 - Taylor & Francis
Inotropic agents are generally recommended to use in patients with acute decompensated
heart failure (HF) with reduced ejection fraction (HFrEF) concurrent to end-organ …