Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …

Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among
patients with major depressive episode remains unknown. Objective To systematically …

Neuropsychiatric disorders (ie, mood disorders and schizophrenia) and inflammation are
closely intertwined, and possibly powering each other in a bidirectional loop. Depression …

Background Ketamine is established as a rapid and effective treatment in adults with
treatment-resistant depression (TRD). The availability of different formulations and routes of …

Introduction Interest in the use of psychedelic substances for the treatment of mental
disorders is increasing. Processes that may affect therapeutic change are not yet fully …

We aimed to analyze the efficacy and safety of arketamine, the R (−)-enantiomer of
ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven …

Background In the past two decades, subanaesthetic doses of ketamine have been
demonstrated to have rapid and sustained antidepressant effects, and accumulating …

Background Intranasal esketamine has received regulatory approvals for the treatment of
depression. Recently a large trial of repeated dose racemic ketamine also demonstrated …

Background Ketamine and its enantiomers have recently been highlighted as one of the
most effective therapeutic options in refractory depression. However, racemic ketamine and …

Objectif: Les patients souffrant de trouble dépressif majeur (TDM) ont souvent une réponse
limitée aux médicaments de première et de deuxième intention, donc de nouveaux …