Beyond hemostasis: platelet innate immune interactions and thromboinflammation

J Mandel, M Casari, M Stepanyan, A Martyanov… - International journal of …, 2022 - mdpi.com
There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases

L Guo, MT Rondina - Frontiers in immunology, 2019 - frontiersin.org
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

ED Hottz, IG Azevedo-Quintanilha… - Blood, The Journal …, 2020 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen
responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel …

Innate immune receptors in platelets and platelet-leukocyte interactions

PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Platelets and infection–an emerging role of platelets in viral infection

A Assinger - Frontiers in immunology, 2014 - frontiersin.org
Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis.
While platelet activation and elevated platelet counts (thrombocytosis) are associated with …

Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2

PS Sung, TF Huang, SL Hsieh - Nature communications, 2019 - nature.com
Platelet-leukocyte interactions amplify inflammatory reactions, but the underlying
mechanism is still unclear. CLEC5A and CLEC2 are spleen tyrosine kinase (Syk)-coupled C …

Thrombocytopenia in virus infections

M Raadsen, J Du Toit, T Langerak… - Journal of clinical …, 2021 - mdpi.com
Thrombocytopenia, which signifies a low platelet count usually below 150× 109/L, is a
common finding following or during many viral infections. In clinical medicine, mild …

Platelets in immune response to virus and immunopathology of viral infections

ED Hottz, FA Bozza, PT Bozza - Frontiers in medicine, 2018 - frontiersin.org
Platelets are essential effector cells in hemostasis. Aside from their role in coagulation,
platelets are now recognized as major inflammatory cells with key roles in the innate and …

Role of platelets in detection and regulation of infection

I Portier, RA Campbell - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Platelets are classically known as essential mediators of hemostasis and thrombosis.
However, in recent years, platelets have gained recognition for their inflammatory functions …

Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators

EL Azeredo, RQ Monteiro… - Mediators of …, 2015 - Wiley Online Library
Dengue is an infectious disease caused by dengue virus (DENV). In general, dengue is a
self‐limiting acute febrile illness followed by a phase of critical defervescence, in which …