Hantavirus in humans: a review of clinical aspects and management

PA Vial, M Ferrés, C Vial, J Klingström… - The Lancet Infectious …, 2023 - thelancet.com
Hantavirus infections are part of the broad group of viral haemorrhagic fevers. They are also
recognised as a distinct model of an emergent zoonotic infection with a global distribution …

Common themes in zoonotic spillover and disease emergence: Lessons learned from bat-and rodent-borne RNA viruses

EP Williams, BM Spruill-Harrell, MK Taylor, J Lee… - Viruses, 2021 - mdpi.com
Rodents (order Rodentia), followed by bats (order Chiroptera), comprise the largest
percentage of living mammals on earth. Thus, it is not surprising that these two orders …

A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples

SN Naccache, S Federman, N Veeraraghavan… - Genome …, 2014 - genome.cshlp.org
Unbiased next-generation sequencing (NGS) approaches enable comprehensive pathogen
detection in the clinical microbiology laboratory and have numerous applications for public …

Evaluation of Phi6 persistence and suitability as an enveloped virus surrogate

N Aquino de Carvalho, EN Stachler… - … science & technology, 2017 - ACS Publications
Recent outbreaks involving enveloped viruses, such as Ebola virus, have raised questions
regarding the persistence of enveloped viruses in the water environment. Efforts have been …

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

E Mittler, AZ Wec, J Tynell, P Guardado-Calvo… - Science translational …, 2022 - science.org
The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic
fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus …

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

LM Kleinfelter, RK Jangra, LT Jae, AS Herbert, E Mittler… - MBio, 2015 - Am Soc Microbiol
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in the Old World and a
highly fatal hantavirus cardiopulmonary syndrome (HCPS) in the New World. No vaccines or …

The evolution and emergence of hantaviruses

EC Holmes, YZ Zhang - Current opinion in virology, 2015 - Elsevier
Highlights•Biodiversity surveys have revealed additional mammalian hosts of
hantaviruses.•Rodents, bats, and Soricomorpha (moles and shrews) are the most common …

Mechanistic insight into bunyavirus-induced membrane fusion from structure-function analyses of the hantavirus envelope glycoprotein Gc

P Guardado-Calvo, EA Bignon, E Stettner… - PLoS …, 2016 - journals.plos.org
Hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents,
giving rise to serious outbreaks of hemorrhagic fever with renal syndrome (HFRS) or of …

Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody

R Stass, TB Engdahl, NS Chapman, RM Wolters… - Nature …, 2023 - nature.com
Rodent-borne hantaviruses are prevalent worldwide and upon spillover to human
populations, cause severe disease for which no specific treatment is available. A potent …

Animal models for the study of rodent‐borne hemorrhagic fever viruses: arenaviruses and hantaviruses

JW Golden, CD Hammerbeck… - BioMed research …, 2015 - Wiley Online Library
Human pathogenic hantaviruses and arenaviruses are maintained in nature by persistent
infection of rodent carrier populations. Several members of these virus groups can cause …