[HTML][HTML] Role of tumor microenvironment in tumorigenesis
M Wang, J Zhao, L Zhang, F Wei, Y Lian, Y Wu… - Journal of …, 2017 - ncbi.nlm.nih.gov
Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …
[HTML][HTML] Biology and clinical relevance of EpCAM
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily
known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression …
known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression …
Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside
Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …
also participates in the development and progression of cancer. In recent decades …
Epithelial cell adhesion molecule: an anchor to isolate clinically relevant circulating tumor cells
In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received
increased attention as the main membrane marker used in many enrichment technologies to …
increased attention as the main membrane marker used in many enrichment technologies to …
Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
X Yuan, H Wu, N Han, H Xu, Q Chu, S Yu… - Journal of hematology & …, 2014 - Springer
Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of
migration and invasion, stem cell like characteristics and therapeutic resistance. Notch …
migration and invasion, stem cell like characteristics and therapeutic resistance. Notch …
Alpha-smooth muscle actin-positive cancer-associated fibroblasts secreting osteopontin promote growth of luminal breast cancer
A Muchlińska, A Nagel, M Popęda, J Szade… - Cellular & Molecular …, 2022 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) have been shown to support
tumor development in a variety of cancers. Different markers were applied to classify CAFs …
tumor development in a variety of cancers. Different markers were applied to classify CAFs …
[HTML][HTML] Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling
A Cruz-Bermúdez, R Laza-Briviesca… - Free Radical Biology …, 2019 - Elsevier
Lung cancer is a major public health problem due to its high incidence and mortality rate.
The altered metabolism in lung cancer is key for the diagnosis and has implications on both …
The altered metabolism in lung cancer is key for the diagnosis and has implications on both …
Integrin-mediated TGFβ activation modulates the tumour microenvironment
NF Brown, JF Marshall - Cancers, 2019 - mdpi.com
TGFβ (transforming growth factor-beta) is a pleotropic cytokine with contrasting effects in
cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting …
cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting …
Therapeutic targeting of TGF‐β in lung cancer
Transforming growth factor‐β (TGF‐β) plays a complex role in lung cancer pathophysiology,
initially acting as a tumor suppressor by inhibiting early‐stage tumor growth. However, its …
initially acting as a tumor suppressor by inhibiting early‐stage tumor growth. However, its …
The role of integrins in TGFβ activation in the tumour stroma
Z Khan, JF Marshall - Cell and tissue research, 2016 - Springer
TGFβ1 is the most pleiotropic of all known cytokines and thus, to avoid uncontrolled TGFβ-
activated processes, its activity is tightly regulated. Studies in fibrosis have led to the …
activated processes, its activity is tightly regulated. Studies in fibrosis have led to the …