Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously
unrecognized, potent, age-related, and common risk factor for atherosclerosis. Somatic …

Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …

Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with an
increased risk of cardiovascular (CV) disease in the general population. Currently, it is …

Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …

Human aging is marked by the emergence of a tapestry of clonal expansions in dividing
tissues, particularly evident in blood as clonal hematopoiesis (CH). CH, linked to cancer risk …

Somatic mutations (also known as acquired mutations) are emerging as common, age-
related processes that occur in all cells throughout the body. Somatic mutations are …

Clonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for
myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial …

Background: Risk factors including smoking, alcohol intake, physical activity (PA), and sleep
patterns have been associated with cancer risk. Clonal hematopoiesis (CH), including …

Clonal hematopoiesis (CH) is nearly universal in the elderly. The molecular and cellular
mechanisms driving CH and the clinical consequences of carrying clonally derived mutant …

Abstract Background Mesenchymal stem cells (MSCs) play important roles in tissue
homeostasis by providing a supportive microenvironmental niche for the hematopoietic …