Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

Background Polyphenols are a class of naturally sourced compounds with widespread
distribution and an extensive array of bioactivities. However, due to their complex …

The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …

In December 2019, a pneumonia outbreak of unknown etiology was reported which caused
panic in Wuhan city of central China, which was later identified as Coronavirus disease …

Interactions between the microbiota and mammalian host are essential for defense against
infection, but the microbial-derived cues that mediate this relationship remain unclear. Here …

Immune cell trafficking is a complex and tightly regulated process that is indispensable for
the body's fight against pathogens. However, it is also increasingly acknowledged that …

Emerging evidence suggests that the effect of dietary intake on human health and disease is
linked to both the immune system and the microbiota. Yet, we lack an integrated mechanistic …

Background The maternal microbiota affects the development of the offspring by microbial
metabolites translocating to the fetus. To reveal the spectrum of these molecular mediators …

The gastrointestinal tract (GIT) is considered the largest immunological organ, with a diverse
gut microbiota, that contributes to combatting pathogens and maintaining human health …