The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

High-throughput DNA sequencing significantly contributed to diagnosis and prognostication
in patients with myelodysplastic syndromes (MDS). We determined the biological and …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as
transcriptional regulators of the Type I interferon system. Thanks to consistent advances …

Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of
five markers in chromosome 5q31. 1 with a gene controlling total serum immunoglobulin E …

Summary Interferon regulatory factor 1 (IRF-1), a transcriptional activator, and its
antagonistic repressor, IRF-2, were originally identified as regulators of the type I interferon …

Interferons are a large family of multifunctional secreted proteins involved in antiviral
defense, cell growth regulation and immune activation. Viral infection induces transcription …

Cytokines are soluble proteins that allow for communication between cells and the external
environment. Interferon (IFN) alpha, the first cytokine to be produced by recombinant DNA …