To capture the full spectrum of genetic risk for autism, we performed a two-stage analysis of
rare de novo and inherited coding variants in 42,607 autism cases, including 35,130 new …

Hierarchy provides a unifying principle for the macroscale organization of anatomical and
functional properties across primate cortex, yet microscale bases of specialization across …

By analyzing the exomes of 12,332 unrelated Swedish individuals, including 4,877
individuals affected with schizophrenia, in ways informed by exome sequences from 45,376 …

Polygenic risk scores have identified that genetic variants without genome‐wide significance
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …

Most everyday memories including many episodic‐like memories that we may form
automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a …

The transcriptional underpinnings of brain development remain poorly understood,
particularly in humans and closely related non-human primates. We describe a high …

The advances in mass spectrometry based proteomics in the past 15 years have contributed
to a deeper appreciation of protein networks and the composition of functional synaptic …

Cellular compartments that cannot be biochemically isolated are challenging to
characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that …

The turnover of brain proteins is critical for organism survival, and its perturbations are linked
to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are …

Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein
thought to act as a global transcriptional repressor. Here we show, using an isogenic human …