Regioselective synthesis of fused pyrimidines and quinazolines linked to Phenoxy‐N‐arylacetamide moieties as novel hybrid molecules via Biginelli‐like reaction

AM Abdelmoniem, RE Abdelwahab… - Journal of …, 2023 - Wiley Online Library
A novel series of 6‐acetyl‐[1, 2, 4] triazolo [1, 5‐a] pyrimidines, hexahydro‐[1, 2, 4] triazolo
[5, 1‐b] quinazolines, tetrahydrobenzo [4, 5] imidazo [2, 1‐b] quinazolin‐1‐ones, and 3 …

Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity

ME Salem, IA Abdelhamid, AHM Elwahy, MA Ragheb… - Heliyon, 2024 - cell.com
The reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-
thiosemicarbazones, or 4-amino-3-mercapto-1, 2, 4-triazole in dioxane in the presence of …

Synthesis, antimicrobial, DNA binding, and computational studies of some bis-and poly (4-methyl-2H-chromen-2-one) derivatives

IMZ Fares, MA Ragheb, IA Abdelhamid… - Journal of Molecular …, 2025 - Elsevier
The research focused on studying how 7-hydroxy-4-methyl-2H-chromen-2-one can be used
as a building material for new bis-and poly (coumarins) through alkylation with related bis …

Conjugate and regiochemical addition of aminoazoles to 2-(4-(2, 2-dicyanovinyl) phenoxy)-N-arylacetamide affording fused pyrimidines linked to phenoxy-N …

RE Abdelwahab, MA Ragheb, AHM Elwahy… - Journal of Molecular …, 2024 - Elsevier
A facile, and efficient regiochemical synthesis of 7-amino [1, 2, 4] triazolo [1, 5-a] pyrimidine-
6-carbonitriles, or 4-aminobenzo [4, 5] imidazo [1, 2-a] pyrimidine-3-carbonitriles that are …

Novel cyanochalcones as potential anticancer agents: apoptosis, cell cycle arrest, DNA binding, and molecular docking studies

MA Ragheb, HE Abdelrashid, EM Elzayat… - Journal of …, 2024 - Taylor & Francis
In the light of anticancer drug discovery and development, a new series of cyanochalcones
incorporating indole moiety (5a-g) were efficiently synthesized and characterized by different …

[PDF][PDF] One-pot three-component synthesis of 6-aryl-3-(arylamino)-5H-thiazolo [3', 2': 1, 2] pyrimido [4, 5-b] quinolines utilizing 4-amino-6-oxo-pyrimidin-tethered N-aryl …

RS Omar, AM Abdelmoniem, AHM Elwahy… - ARKIVOC, 2024 - arkat-usa.org
Abstract New thiazolo [3', 2': 1, 2] pyrimido [4, 5-b] quinolines were synthesized in good
yields using a three-component Hantzsch reaction comprising the appropriate aldehyde and …