Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review
C Aldecoa, JV Llau, X Nuvials, A Artigas - Annals of Intensive Care, 2020 - Springer
The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans,
secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such …
secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such …
Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS
CM Hendrickson, MA Matthay - Pulmonary circulation, 2018 - journals.sagepub.com
Experimental models of sepsis in small and large animals and a variety of in vitro
preparations have established several basic mechanisms that drive endothelial injury. This …
preparations have established several basic mechanisms that drive endothelial injury. This …
Diagnostic challenges in sepsis
CF Duncan, T Youngstein, MD Kirrane… - Current Infectious …, 2021 - Springer
Abstract Purpose of Review Sepsis is a leading cause of death worldwide. Groundbreaking
international collaborative efforts have culminated in the widely accepted surviving sepsis …
international collaborative efforts have culminated in the widely accepted surviving sepsis …
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
PK Bhatraju, ED Morrell, L Zelnick, NA Sathe, XY Chai… - Critical Care, 2021 - Springer
Background Analyses of blood biomarkers involved in the host response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct …
respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct …
Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis
H Bai, Q Lu, C Wu, F Xu, J Liu, K Wang… - Science Translational …, 2024 - science.org
Defining next-generation immune therapeutics for the treatment of sepsis will involve
biomarker-based therapeutic decision-making. Bone morphogenetic protein 9 (BMP9) is a …
biomarker-based therapeutic decision-making. Bone morphogenetic protein 9 (BMP9) is a …
PD-L1 and PD-1 are associated with clinical outcomes and alveolar immune cell activation in acute respiratory distress syndrome
ED Morrell, SE Holton, A Wiedeman… - American Journal of …, 2024 - atsjournals.org
The relationship between the PD-L1 (Programmed Death-Ligand 1)/PD-1 pathway, lung
inflammation, and clinical outcomes in acute respiratory distress syndrome (ARDS) is poorly …
inflammation, and clinical outcomes in acute respiratory distress syndrome (ARDS) is poorly …
Identification of persistent and resolving subphenotypes of acute hypoxemic respiratory failure in two independent cohorts
NA Sathe, LR Zelnick, C Mikacenic, ED Morrell… - Critical Care, 2021 - Springer
Background Acute hypoxemic respiratory failure (HRF) is associated with high morbidity and
mortality, but its heterogeneity challenges the identification of effective therapies. Defining …
mortality, but its heterogeneity challenges the identification of effective therapies. Defining …
Potential networks regulated by MSCs in acute-on-chronic liver failure: exosomal miRNAs and intracellular target genes
J Zhang, J Gao, D Lin, J Xiong, J Wang, J Chen… - Frontiers in …, 2021 - frontiersin.org
Acute-on-chronic liver failure (ACLF) is a severe syndrome associated with high mortality.
Alterations in the liver microenvironment are one of the vital causes of immune damage and …
Alterations in the liver microenvironment are one of the vital causes of immune damage and …
Biomarker signatures of severe acute kidney injury in a critically ill cohort of COVID-19 and non-COVID-19 acute respiratory illness
NA Sathe, A Mostaghim, E Barnes… - Critical Care …, 2023 - journals.lww.com
Biomarker Signatures of Severe Acute Kidney Injury in a Crit... : Critical Care Explorations
Biomarker Signatures of Severe Acute Kidney Injury in a Critically Ill Cohort of COVID-19 and …
Biomarker Signatures of Severe Acute Kidney Injury in a Critically Ill Cohort of COVID-19 and …
A prediction model for severe AKI in critically ill adults that incorporates clinical and biomarker data
PK Bhatraju, LR Zelnick, R Katz… - Clinical Journal of the …, 2019 - journals.lww.com
Results Severe AKI developed in 62 (8%) patients in the derivation, 26 (8%) patients in the
internal validation, and 15 (6%) patients in the external validation cohorts. In the derivation …
internal validation, and 15 (6%) patients in the external validation cohorts. In the derivation …