[HTML][HTML] The silent threat to women's fertility: uncovering the devastating effects of oxidative stress

A Kaltsas, A Zikopoulos, E Moustakli, A Zachariou… - Antioxidants, 2023 - mdpi.com
Oxidative stress (OS), which arises through an imbalance between the formation of reactive
oxygen species (ROS) and antioxidant defenses, plays a key role in the pathophysiology of …

[HTML][HTML] Role of microRNAs in trophoblast invasion and spiral artery remodeling: implications for preeclampsia

H Hayder, Y Shan, Y Chen, JA O'Brien… - Frontiers in Cell and …, 2022 - frontiersin.org
It is now well-established that microRNAs (miRNAs) are important regulators of gene
expression. The role of miRNAs in placental development and trophoblast function is …

[HTML][HTML] Prioritization of potential causative genes for schizophrenia in placenta

G Ursini, P Di Carlo, S Mukherjee, Q Chen… - Nature …, 2023 - nature.com
Our earlier work has shown that genomic risk for schizophrenia converges with early life
complications in affecting risk for the disorder and sex-biased neurodevelopmental …

New immune horizons in therapeutics and diagnostic approaches to Preeclampsia

I Mukherjee, S Singh, A Karmakar… - American Journal of …, 2023 - Wiley Online Library
Hypertensive disorders of pregnancy (HDP) are one of the commonest maladies, affecting
5%–10% of pregnancies worldwide. The American College of Obstetricians and …

Cytoprotective and genoprotective effects of taxifolin against oxidative damage in HTR-8/SVneo human trophoblast cells

M Bruić, A Pirković, A Vilotić… - …, 2023 - academic.oup.com
An increase of reactive oxygen species in the placenta and oxidative disbalance has been
recognized as a significant factor contributing to pregnancy complications. Dietary intake of …

Modeling the Progression of Placental Transport from Early‐to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization

S Kouthouridis, A Sotra, Z Khan… - Advanced …, 2023 - Wiley Online Library
The early‐stage placental barrier is characterized by a lack of fetal circulation and by a thick
trophoblastic barrier, whereas the later‐stage placenta consists of vascularized chorionic …

[HTML][HTML] Crosstalk between microRNA and oxidative stress in heart failure: A systematic review

D Klimczak-Tomaniak, J Haponiuk-Skwarlińska… - International Journal of …, 2022 - mdpi.com
Heart failure is defined as a clinical syndrome consisting of key symptoms and is due to a
structural and/or functional alteration of the heart that results in increased intracardiac …

[HTML][HTML] Oleuropein attenuates oxidative stress in human trophoblast cells

A Pirković, A Vilotić, S Borozan, M Nacka-Aleksić… - Antioxidants, 2023 - mdpi.com
Olive-derived bioactive compound oleuropein was evaluated against damage induced by
hydrogen peroxide in human trophoblast cells in vitro, by examining the changes in several …

[HTML][HTML] Reduction in CgA-Derived CST Protein Level in HTR-8/SVneo and BeWo Trophoblastic Cell Lines Caused by the Preeclamptic Environment

M Bralewska, T Pietrucha, A Sakowicz - International Journal of …, 2023 - mdpi.com
One of the most dangerous complications of pregnancy is preeclampsia (PE), a disease
associated with a high risk of maternal and fetal mortality and morbidity. Although its etiology …

[HTML][HTML] Monosodium glutamate perturbs human trophoblast invasion and differentiation through a reactive oxygen species-mediated pathway: An in-vitro assessment

I Mukherjee, S Biswas, S Singh, J Talukdar… - Antioxidants, 2023 - mdpi.com
The overproduction of reactive oxygen species (ROS) has been associated with various
human diseases. ROS exert a multitude of biological effects with both physiological and …