Nutritional immunity: the battle for nutrient metals at the host–pathogen interface

CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …

[HTML][HTML] Zinc and respiratory tract infections: Perspectives for COVID‑19

AV Skalny, L Rink, OP Ajsuvakova… - International …, 2020 - spandidos-publications.com
In view of the emerging COVID‑19 pandemic caused by SARS‑CoV‑2 virus, the search for
potential protective and therapeutic antiviral strategies is of particular and urgent interest …

[HTML][HTML] The potential impact of zinc supplementation on COVID-19 pathogenesis

I Wessels, B Rolles, L Rink - Frontiers in immunology, 2020 - frontiersin.org
During the current corona pandemic, new therapeutic options against this viral disease are
urgently desired. Due to the rapid spread and immense number of affected individuals …

[HTML][HTML] The role of zinc in antiviral immunity

SA Read, S Obeid, C Ahlenstiel, G Ahlenstiel - Advances in nutrition, 2019 - Elsevier
Zinc is an essential trace element that is crucial for growth, development, and the
maintenance of immune function. Its influence reaches all organs and cell types …

Zinc as a gatekeeper of immune function

I Wessels, M Maywald, L Rink - Nutrients, 2017 - mdpi.com
After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential
for the function of the immune system. Zinc ions are involved in regulating intracellular …

Zinc in infection and inflammation

NZ Gammoh, L Rink - Nutrients, 2017 - mdpi.com
Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an
essential micronutrient that is involved in the regulation of the innate and adaptive immune …

Role of zinc in immune system and anti-cancer defense mechanisms

D Skrajnowska, B Bobrowska-Korczak - Nutrients, 2019 - mdpi.com
The human body cannot store zinc reserves, so a deficiency can arise relatively quickly, eg,
through an improper diet. Severe zinc deficiency is rare, but mild deficiencies are common …

Zinc in wound healing modulation

PH Lin, M Sermersheim, H Li, PHU Lee, SM Steinberg… - Nutrients, 2017 - mdpi.com
Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma
wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with …

Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

J Olechnowicz, A Tinkov, A Skalny… - The journal of …, 2018 - Springer
A number of studies have reported that zinc plays a substantial role in the development of
metabolic syndrome, taking part in the regulation of cytokine expression, suppressing …

Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling

M Jarosz, M Olbert, G Wyszogrodzka, K Młyniec… - …, 2017 - Springer
Zinc is a nutritionally fundamental trace element, essential to the structure and function of
numerous macromolecules, including enzymes regulating cellular processes and cellular …