Ion mobility spectrometry‐mass spectrometry (IMS‐MS) of small molecules: Separating and assigning structures to ions

C Lapthorn, F Pullen… - Mass spectrometry …, 2013 - Wiley Online Library
The phenomenon of ion mobility (IM), the movement/transport of charged particles under the
influence of an electric field, was first observed in the early 20th Century and harnessed later …

High-sensitivity analytical approaches for the structural characterization of glycoproteins

WR Alley Jr, BF Mann, MV Novotny - Chemical reviews, 2013 - ACS Publications
1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

Identification of carbohydrate anomers using ion mobility–mass spectrometry

J Hofmann, HS Hahm, PH Seeberger, K Pagel - Nature, 2015 - nature.com
Carbohydrates are ubiquitous biological polymers that are important in a broad range of
biological processes,,. However, owing to their branched structures and the presence of …

Resolution of isomeric mixtures in ion mobility using a combined demultiplexing and peak deconvolution technique

JC May, R Knochenmuss, JC Fjeldsted… - Analytical …, 2020 - ACS Publications
A combined data acquisition and data processing strategy for improving the sensitivity and
resolution of ion mobility measurements is described. This strategy is implemented on a …

Advances in mass spectrometry for lipidomics

SJ Blanksby, TW Mitchell - Annual Review of Analytical …, 2010 - annualreviews.org
Recent expansion in research in the field of lipidomics has been driven by the development
of new mass spectrometric tools and protocols for the identification and quantification of …

Glycan analysis by ion mobility–mass spectrometry

J Hofmann, K Pagel - Angewandte Chemie International …, 2017 - Wiley Online Library
Carbohydrates form one of the major classes of biological macromolecules in living
organisms. To investigate their properties and function, an in‐depth knowledge of their …

A review of recent, unconventional applications of ion mobility spectrometry (IMS)

S Armenta, M Alcala, M Blanco - Analytica chimica acta, 2011 - Elsevier
The applications of ion mobility spectrometry (IMS) have grown exponentially beyond its
uses for explosive, illicit drug and chemical warfare agent monitoring in recent years …

Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis

CJ Gray, B Thomas, R Upton, LG Migas… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background Diverse varieties of often heterogeneous glycans are ubiquitous in nature. They
play critical roles in recognition events, act as energy stores and provide structural stability at …

Ion mobility studies of carbohydrates as group I adducts: isomer specific collisional cross section dependence on metal ion radius

Y Huang, ED Dodds - Analytical chemistry, 2013 - ACS Publications
Carbohydrates play numerous critical roles in biological systems. Characterization of
oligosaccharide structures is essential to a complete understanding of their functions in …

Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples

KE Burnum-Johnson, X Zheng, JN Dodds, J Ash… - TrAC Trends in …, 2019 - Elsevier
Ion mobility spectrometry (IMS) is a widely used analytical technique providing rapid gas
phase separations. IMS alone is useful, but its coupling with mass spectrometry (IMS-MS) …