The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and
novel treatments are urgently needed. Current therapeutic approaches for diabetic …

Diabetic nephropathy (DN), a severe microvascular complication frequently associated with
both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. The condition …

Diabetes is associated with altered cellular metabolism, but how altered metabolism
contributes to the development of diabetic complications is unknown. We used the BKS …

The prevalence of diabetes is continuously increasing in the recent decades. Persistent
hyperglycemia, hyperinsulinemia and the subsequent oxidative stress result in diabetic …

Abstract TGF-β1 upregulates microRNA-192 (miR-192) in cultured glomerular mesangial
cells and in glomeruli from diabetic mice. miR-192 not only increases collagen expression …

Myocardial ischemia-reperfusion injury (MIRI) is a serious threat to the health and lives of
patients without any effective therapy. Excessive production of reactive oxygen species …

Akt kinase is activated by transforming growth factor-β1 (TGF-β) in diabetic kidneys, and has
important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells …