The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

T cell activation, proliferation, and differentiation into effector and memory states involve
massive remodeling of T cell size and molecular content and create a massive increase in …

Protein synthesis is one of the most energy consuming processes in the cell. The
mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

BACKGROUND How do the different cell types in our bodies maintain their distinctive and
characteristic sizes? Although much is known about the signaling networks that stimulate or …

The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …

The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

Protein synthesis is principally regulated at the initiation stage (rather than during elongation
or termination), allowing rapid, reversible and spatial control of gene expression. Progress …

Cellular senescence is thought to contribute to age-associated deterioration of tissue
physiology. The senescence effector p16Ink4a is expressed in pancreatic beta cells during …