Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Abstract N 6-methyladenosine (m6A) is the most abundant epigenetic modification of RNA,
and its dysregulation drives aberrant transcription and translation programs that promote …

The progression of cancer is not only about the tumor cell itself, but also about other
involved players including cancer cell recruited immune cells, their released pro …

The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …

RNA methylation is a kind of RNA modification that exists widely in eukaryotes and
prokaryotes. RNA methylation occurs not only in mRNA but also in ncRNA. According to the …

Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

Neutrophils are the first responders to inflammation, infection, and injury. As one of the most
abundant leukocytes in the immune system, neutrophils play an essential role in cancer …

Gynecological and breast cancers are a group of heterogeneous malignant tumors.
Although existing treatment strategies have ameliorated the clinical outcomes of patients …

The mammalian target of rapamycin (mTOR) pathway regulates major processes by
integrating a variety of exogenous cues, including diverse environmental inputs in the tumor …

Macrophages are cells of innate immunity and are derived from circulating monocytes and
embryonic yolk sac. They exhibit high plasticity and polarize functionally in response to …