The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

The Eph/ephrin receptor–ligand system plays an important role in embryogenesis and adult
life, principally by influencing cell behavior through signaling pathways, resulting in …

Angiogenesis research in the past two decades has contributed significantly towards
understanding the molecular pathophysiology of cancer progression and inspired target …

Since the establishment of tumor angiogenesis as a therapeutic target, an excitement in
developing the anti-angiogenic agents was resulted in tailoring a humanized monoclonal …

EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel
development and vascular remodeling. In addition, several reports suggest that this receptor …

Backgrounds Allergic airway inflammation is prevalent worldwide and imposes a
considerable burden on both society and affected individuals. This study aimed to …

Microvascular disease, a characteristic of acute and chronic kidney diseases, leads to
rarefaction of peritubular capillaries (PTCs), promoting secondary ischemic injury, which …

The induction of tumor vasculature, known as the 'angiogenic switch', is a rate-limiting step
in tumor progression. Normal blood vessels are composed of two distinct cell types …

Objective—Endothelial cell activation results in altered cell-cell interactions with adjacent
endothelial cells and with infiltrating leukocytes. Eph receptors and their ephrin ligands …