Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Nutrient sensing is a mechanism for organisms to sense their environment. In larger
animals, including humans, the intestinal tract is a major site of nutrient sensing for the body …

Uveal melanoma, the most common eye malignancy, causes severe visual morbidity and is
fatal in approximately 50% of patients. Primary uveal melanoma can be cured by surgery or …

In current clinical practice, microsatellite instability (MSI) and mismatch repair deficiency
detection is performed with MSI-PCR and immunohistochemistry. Recent research has …

The immune system can recognize and attack cancer cells, especially those with a high load
of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair …

Deficient DNA mismatch repair (MMR) boosts the accumulation of frameshift mutations in
genes encompassing coding microsatellites (cMS). This results in the translation of proteins …

Purpose Microsatellites are widely distributed repetitive DNA motifs, accounting for
approximately 3% of the genome. Due to mismatch repair system deficiency, insertion or …

Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …

Introduction Advances in our understanding of the molecular genetics and epigenetics of
colorectal cancer have led to novel insights into the pathogenesis of this common cancer …

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …