Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

Glutamine and glutamate with proline, histidine, arginine and ornithine, comprise 25% of the
dietary amino acid intake and constitute the “glutamate family” of amino acids, which are …

Responsible for the majority of excitatory activity in the central nervous system (CNS),
glutamate interacts with a range of specific receptor and transporter systems to establish a …

The pathogenesis of Huntington's disease is still not completely understood. Several lines of
evidence from toxic/non‐transgenic animal models of Huntington's disease suggest that …

Excitotoxicity may play a role in certain disorders of the motor system thought to be caused
by environmentally acquired toxins, including lathyrism and domoic acid poisoning. Motor …

Huntington's disease (HD) is a late-onset neurodegenerative disease for which the mutation
is CAG/polyglutamine repeat expansion. The R6 mouse lines expressing the HD mutation …

Microdialysis has become a frequently used method to study extracellular levels of GABA
and glutamate in the central nervous system. However, the fact that the major part of GABA …

This review is a critical appraisal of the widespread assumption that high extracellular
glutamate, resulting from enhanced pre-synaptic release superimposed on deficient uptake …

Bioenergetic defects and abnormalities in glutamate neurotransmission have both been
proposed to play important roles in neurological diseases of varying chronology, etiology …

Infusion of the K+ channel blocker 4-aminopyridine in the hippocampus induces the release
of glutamate, as well as seizures and neurodegeneration. Since an imbalance between …