Over the course of three decades of study, the deubiquitinase Herpesvirus associated
Ubiquitin-Specific Protease/Ubiquitin-Specific Protease 7 (HAUSP/USP7) has gradually …

The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …

Neuroinflammation is a fundamental contributor to progressive neuronal damage, which
arouses a heightened interest in neurodegenerative disease therapy. Ubiquitin-specific …

Spinal and bulbar muscular atrophy (SBMA) is an X-linked, neuromuscular
neurodegenerative disease for which there is no cure. The disease is characterized by a …

Despite annual increases in the incidence and prevalence of neurodegenerative diseases,
there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the N-terminus of the HTT gene. The CAG repeat expansion translates into a …

Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative and neuromuscular
genetic disease caused by the expansion of a polyglutamine-encoding CAG tract in the …

Ferroptosis is a form of cell death mediated by iron and lipid peroxidation (LPO). Recent
studies have provided compelling evidence to support the involvement of ferroptosis in the …

Spinal and bulbar muscular atrophy (SBMA) is a slowly progressing neuromuscular disease
caused by a polyglutamine (polyQ)-encoding CAG trinucleotide repeat expansion in the …

A major mechanism to modulate the biological activities of the androgen receptor (AR)
involves a growing number of post-translational modifications (PTMs). In this review we …