Many tocopherols, one vitamin E

A Azzi - Molecular aspects of medicine, 2018 - Elsevier
Four tocopherols are available in nature and are absorbed with the diet, but only one RRR-α-
tocopherol satisfies the criteria of being a vitamin. The biological activity of the different …

Antioxidant, anti-inflammatory, and metabolic properties of tocopherols and tocotrienols: clinical implications for vitamin E supplementation in diabetic kidney disease

A Di Vincenzo, C Tana, H El Hadi, C Pagano… - International Journal of …, 2019 - mdpi.com
Diabetes mellitus is a metabolic disorder characterized by the development of vascular
complications associated with high morbidity and mortality and the consequent relevant …

Efficacy mechanisms research progress of the active components in the characteristic woody edible oils

L Xu, W Wang, K Bai, Y Wu, Y Ling, X Kong… - Food …, 2023 - Wiley Online Library
Woody edible oils are a type of vegetable oil. Woody edible oils like olive oil have greater
quantities of unsaturated fatty acids (UFAs), particularly essential FAs, as well as vitamin E …

Antihypertensive effects of Tartary buckwheat flavonoids by improvement of vascular insulin sensitivity in spontaneously hypertensive rats

Z Hou, Y Hu, X Yang, W Chen - Food & function, 2017 - pubs.rsc.org
Vascular insulin resistance and oxidative stress contribute to endothelial dysfunction and
hypertension. The present study investigated whether chronic treatment with purified Tartary …

Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions

Y Qian, PVA Babu, JD Symons, T Jalili - Nutrition & Diabetes, 2017 - nature.com
We hypothesized that metabolites of dietary flavonoids attenuate impairments in nitric oxide
(NO) bioavailability evoked by glucotoxic conditions mimicking Type 1 or 2 diabetes. To test …

Evaluation of oxidative stress and brain-derived neurotrophic factor levels related to crack-use detoxification

GE Hirsch, M Jaskulski, HM Hamerski, FG Porto… - Neuroscience …, 2018 - Elsevier
Crack is a central nervous system stimulant extracted from the Erythroxylum coca plant. It is
considered the most potent and addictive form of cocaine, and its euphoric effects are …

[HTML][HTML] Endothelial protein C–targeting liposomes show enhanced uptake and improved therapeutic efficacy in human retinal endothelial cells

A Arta, AZ Eriksen, F Melander… - … & visual science, 2018 - tvst.arvojournals.org
Purpose: To determine whether human retinal endothelial cells (HRECs) express the
endothelial cell protein C receptor (EPCR) and to realize its potential as a targeting moiety …

In vitro and In vivo oxidation and cleavage products of tocols: From chemical tuners to “VitaminEome” therapeutics. A narrative review

F Khallouki, S Saber, T Bouddine, L Hajji, B Elbouhali… - Food Bioscience, 2022 - Elsevier
Vitamin E components and vitamin E oxidation products (VEOP) define the “vitaminEome”.
VEOP are produced through biological and chemical processes. They are found at low …

Improved hepatic γ-tocopherol status limits oxidative and inflammatory stress-mediated liver injury in db/db mice with nonalcoholic steatohepatitis

P Dey, E Mah, J Li, T Jalili, JD Symons… - Journal of Functional …, 2018 - Elsevier
Abstract γ-Tocopherol (γ-T) and its physiological metabolite γ-carboxyethyl-hydroxychroman
(γ-CEHC) exhibit antioxidant and anti-inflammatory activities. We hypothesized that …

Endothelial dysfunction in patients with severe mitral regurgitation

B Porro, P Songia, VA Myasoedova, V Valerio… - Journal of Clinical …, 2019 - mdpi.com
Mitral valve prolapse (MVP) is the most common cause of severe mitral regurgitation. It has
been reported that MVP patients—candidates for mitral valve repair (MVRep)—showed an …