Abstract Purpose of Review To describe the effects of type 1 diabetes on bone cells. Recent
findings Type 1 diabetes (T1D) is associated with low bone mineral density, increased risk of …

Abstract Purpose of Review Osteocytes comprise> 95% of the cellular component in bone
tissue and produce a wide range of cytokines and cellular signaling molecules in response …

Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-
canalicular pore system (LCS) buried within the mineralized matrix, which allows osteocytes …

Context Skeletal fragility is a significant complication of type 1 diabetes (T1D), with an
increased risk of fracture observed starting in childhood. Altered bone accrual and …

Diabetes mellitus (DM) is a chronic disease that results in a variety of systemic
complications. Recently, stem cell-based therapies have been proposed as potential …

There is an unmet need to understand the mechanisms underlying skeletal deterioration in
diabetes mellitus (DM) and to develop therapeutic approaches to treat bone fragility in …

Abstract Introduction Type 2 diabetes (T2D) is related to an increased fracture risk and low
bone turnover. However, the mechanisms are not elucidated. In the present study we …

Osteolytic bone lesions, which develop in many metastatic breast cancer patients, impair
bone integrity and lead to adverse skeletal related events that are difficult to treat and …

Abstract Context Type 1 diabetes (T1D) is characterized by high fracture risk, yet little is
known regarding diabetes-related mechanisms or risk factors. Objective Determine whether …

Type 1 diabetes (T1D) causes a range of skeletal problems, including reduced bone density
and increased risk for bone fractures. However, mechanisms underlying skeletal …