Sortase A is a membrane enzyme responsible for the anchoring of surface-exposed proteins
to the cell wall envelope of Gram-positive bacteria. As a well-studied member of the sortase …

Gram‐positive bacteria pose a serious healthcare threat. The growing antibiotic resistance
epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a …

This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …

C–H amination of N-aryl benzamides with O-benzoyl hydroxylamines has been achieved
with either Pd (II) or Pd (0) catalysts. Furthermore, we demonstrate that secondary amines …

Here, we describe the most promising small synthetic organic compounds that act as potent
Sortase A inhibitors and cater the potential to be developed as antivirulence drugs. Sortase …

The role of a widely employed additive (AgOAc) in a palladium acetate-catalyzed ortho-C–H
bond activation reaction has been examined using the M06 density functional theory. A new …

Targeting virulence factors has gained increasing attention as a potential approach to new
antibiotics. Small molecule inhibitors of virulence have been shown to change the course of …

Bacterial infections have always been, and still are, a major global healthcare problem. For
accurate treatment it is of upmost importance that the location (s), severity, type of bacteria …

Rapid spread of antibiotic resistance throughout the kingdom bacteria is inevitably bringing
humanity towards the “post-antibiotic” era. The emergence of so-called “superbugs” …

Staphylococcus aureus is the leading cause of hospital-acquired infections. The enzyme
sortase A, present on the cell surface of S. aureus, plays a key role in bacterial virulence …