Induction of heat shock proteins for protection against oxidative stress

B Kalmar, L Greensmith - Advanced drug delivery reviews, 2009 - Elsevier
Heat shock proteins (Hsps) have been studied for many years and there is now a large body
of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a …

Heat shock proteins: cellular and molecular mechanisms in the central nervous system

RA Stetler, Y Gan, W Zhang, AK Liou, Y Gao… - Progress in …, 2010 - Elsevier
Emerging evidence indicates that heat shock proteins (HSPs) are critical regulators in
normal neural physiological function as well as in cell stress responses. The functions of …

Structure and function of the small heat shock protein/α-crystallin family of molecular chaperones

R Van Montfort, C Slingsby, E Vierlingt - Advances in protein chemistry, 2001 - Elsevier
Publisher Summary The goal of this chapter is to clarify the diversity within the heat shock
proteins (sHsps) family and to describe evidence indicating that sHsps have many different …

Multiple molecular penumbras after focal cerebral ischemia

FR Sharp, A Lu, Y Tang… - Journal of Cerebral Blood …, 2000 - journals.sagepub.com
Though the ischemic penumbra has been classically described on the basis of blood flow
and physiologic parameters, a variety of ischemic penumbras can be described in molecular …

Identification of ischemic regions in a rat model of stroke

A Popp, N Jaenisch, OW Witte, C Frahm - PloS one, 2009 - journals.plos.org
Background Investigations following stroke first of all require information about the spatio-
temporal dimension of the ischemic core as well as of perilesional and remote affected …

High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1

Z Batulan, GA Shinder, S Minotti, BP He… - Journal of …, 2003 - Soc Neuroscience
Heat shock protein 70 (Hsp70) protects cultured motor neurons from the toxic effects of
mutations in Cu/Zn-superoxide dismutase (SOD-1), which is responsible for a familial form of …

The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system

TB Franklin, AM Krueger-Naug, DB Clarke… - International Journal …, 2005 - Taylor & Francis
Heat shock proteins (Hsps) are highly conserved and under physiological conditions act as
molecular chaperones and/or have anti-apoptotic activities. Expression in the brain of two …

Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes

G Tezel, MR Hernandez, MB Wax - Archives of ophthalmology, 2000 - jamanetwork.com
Purpose To examine immunostaining of 60-kd and 27-kd heat shock proteins (HSP 60 and
HSP 27), which are known to increase cell survival in response to stress, in glaucomatous …

Attenuation of thrombin-induced brain edema by cerebral thrombin preconditioning

G Xi, RF Keep, Y Hua, J Xiang, JT Hoff - Stroke, 1999 - Am Heart Assoc
Background and Purpose—Edema formation after intracerebral hemorrhage has been
linked to thrombin toxicity induced by the clot. However, thrombin at low concentrations …

Heat shock protein 27: developmental regulation and expression after peripheral nerve injury

M Costigan, RJ Mannion, G Kendall… - Journal of …, 1998 - Soc Neuroscience
The heat shock protein (HSP) 27 is constitutively expressed at low levels in medium-sized
lumbar dorsal root ganglion (DRG) cells in adult rats. Transection of the sciatic nerve results …