The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and
soon were proposed as drug delivery systems. The pioneering work of countless liposome …

One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR),
where cancer cells simultaneously become resistant to different anticancer drugs. Over …

Gene and antisense/ribozyme therapy possesses tremendous potential for the successful
treatment of genetically based diseases, such as cancer. Several cancer gene therapy …

A key issue in the treatment of many cancers is the development of resistance to
chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them …

Multidrug resistance (MDR) is a major obstacle to the effective treatment of cancer. One of
the underlying mechanisms of MDR is cellular overproduction of P-glycoprotein (P-gp) …

Abstract ATP Binding Cassette (ABC) transporters, widely studied in cancer for their role in
drug resistance, have been more recently also considered for their contribution to cancer …

Purpose PAMAM G5 dendrimer (P) was conjugated to Tat peptide (T), a cell penetrating
peptide, in search of an efficient cellular delivery vehicle for antisense and siRNA …

The membrane disruption properties of high generation (G4 to G7) poly
(amidoamine)(PAMAM) dendrimers are evaluated and compared to linear poly (lysine). The …

This review presents molecular targeting approaches in anticancer drug delivery systems
(DDS) and identifies new developments in these systems. Targeting approaches include …

PAMAM dendrimers are cationic polymers that have been used for the delivery of genes and
oligonucleotides to cells. However, little is known about the behavior of dendrimer–nucleic …